The Bears (5-3, 2-3 Big 12) gained a school-record 686 yards.
A week after turning an 11-point, fourth-quarter deficit into an overtime win at Texas A&M, the Tigers were down by 14 when the final period began. Mizzou QB, James Franklin, threw three touchdowns as Missouri rallied for 25 points in the quarter, but the Tigers gave up 14 -- on a 68-yard touchdown pass and Ganaway's 80-yarder. Missouri failed to recover a pair of onside kick attempts, and couldn't stop Ganaway on a third-and-2, giving Baylor the game-clinching final first down.
"We battled at the end, but it's all about consistency," Tigers coach Gary Pinkel said. "We make a lot of mistakes -- a lot of fundamental, discipline, basic mistakes on both sides of the football. And it makes it very difficult to win when you're doing it. I'm responsible that we play better. They're a really good football team, and I'm disappointed and I expected to play better."
"He's real tough to get a hold of when he's in the pocket," defensive end Brad Madison said. "We missed him a couple of times when he slipped out and made a big play."
Griffin was most impressed by Ganaway's touchdowns -- a zigzagging run for the 38-yard TD and a burst along the sideline that went for 80 yards.
"You don't see that from a 240-pound back," Griffin said. "I was amazed. ... I think the cutback was better, but the 80-yarder was impressive. ... He's faster than you think he is. You're not going to run him down in the open field."
The Bears were coming off consecutive lopsided losses and in a 1-3 funk since climbing to No. 15 in the nation. They fell behind the Tigers 7-0 and 14-7, then roared back to lead 28-14 on Ganaway's first touchdown. They ended up needing an onside kick recovery and one final first down by Ganaway to seal the victory.
It's a significant win, too, as Baylor improved to 5-0 at home and is now one win from being bowl eligible for a second straight season. The Bears, who haven't been to bowls in consecutive seasons since 1991-92, could practically wrap that up by winning at lowly Kansas next weekend.
"For our guys to come fight and play with a lot of confidence says a lot about their faith and belief in themselves and our programs," coach Art Briles said.
Perhaps days from joining the Southeastern Conference, Missouri (4-5, 2-4) clearly lacked the stingy defense it's going to need to compete in that league. Baylor fans pointed that out by chanting "S-E-C! S-E-C!" in the final minute, right after Ganaway's game-sealing run.
"You've got to get out of drives (defensively)," Pinkel said. "First half, we get out of drives. Second half, we didn't get out of drives and then they had some big plays."
Missouri's Henry Josey, who came in leading the Big 12 in rushing, ran for 132 yards and two touchdowns. It was his fourth straight game with at least 129 yards. Franklin was 33 of 46 for 325 yards, and he ran 16 times for 57 yards.
Griffin -- who came in as the second-most accurate quarterback in the nation, and third in total offense -- was 27 of 41. His best pass was a heave that hit Tevin Reese in stride for the 68-yard TD. Reese bobbled it and stepped out of an ankle tackle around the 10-yard line. Griffin also ran 19 times for 53 yards.
Ganaway had 186 yards on just 12 carries.
The game got off to a bit of an odd start, with each team's first possession ending with a 9-yard punt. Only Missouri's was into the wind. Kicking was a problem all game for the Bears, as they had a point-after blocked and missed field goals of 27 and 54 yards.